Endocrine Abstracts

Background: Adiponectin is a protein hormone secreted by adipocytes. Its expression is higher in lean than in obese individuals and in women than in men. It inhibits expression of gluconeogenic enzymes and the rate of glucose production. It also stimulates glucose utilization and fatty acids oxidation. Adiponectin is encoded by a highly polymorphic ADIPOQ gene. The −11377C>G, −11391G>A, and −11426A>G ADIPOQ polymorphisms modulate cir...

Introduction: Leptin is a protein hormone secreted mainly by adipose tissue. It exerts its function via ubiquitously expressed receptors (LEPR). A number of LEPR isoforms are known. Metabolism of lipids and carbohydrates, that, in part, depends on leptin, might deteriorate with age. Aging is associated with a decrease of the global methylation and with hypermethylation of some promoter-located CpG islands. Such hypermethylation results in transcription inhibition.<p class=...